Salvia Miltiorrhiza extract can be divided into fat-soluble extract and water-soluble extract.

The liposoluble extracts include tanshinone 1, dihydrotanshinone, tanshinone IIA, cryptotanshinone, tanshinone IIB, methyltanshinone, tanshinone, hydroxytanshinone and so on.

The water-soluble extracts include Danshensu, salvianolic acid B, original tea aldehyde, salvianolic acid a, rosmarinic acid, caffeic acid, shikonic acid, etc...

Salvia Miltiorrhiza extract

Histroy of Traditional Chinese Medicine(TCM)

From Shennong’s tasting of herbs, to the Shennong Ben Cao Jing of the late eastern Han Dynasty, and the 16th century’s Bencao Gangmu, written by Li Shizhen, the efficacy of Chinese herbal medicine has become increasingly clear. As modern diseases become more complex and intractable, drug development is not limited to organic synthesis; more and more drugs or compounds are derived from Chinese herbs. Some compounds start out as specific ingredients in Chinese herbal medicines, and once you understand their structure, you can use organic chemistry or microbes to synthesize them. Common Herbs such as Ganoderma Lucidum, Ginseng and Ophiocordyceps sinensis are the most commonly used herbs and are often used as medicine or dietary supplement.

In recent years for the development of Chinese herbal medicine is more important, no matter at home and abroad many pharmaceutical companies are competing to invest a lot of R & D funds. In addition to Ganoderma Lucidum, Ginseng and Ophiocordyceps sinensis, Salvia Miltiorrhiza is one of the many Chinese herbs studied.

What is Salvia Miltiorrhiza?

Salvia Miltiorrhiza is a perennial plant plant derived from the dry root of the plant, which is red in color and has healing properties derived from its roots. Salvia Miltiorrhiza is found in most parts of China, so it is also called Red Salvia Miltiorrhiza, red Salvia Miltiorrhiza and red root.

It is mainly found in Sichuan, Jiangsu, Anhui, Hebei and Shanxi. Salvia Miltiorrhiza first appeared in the Shennong Ben Cao Jing, which is classified as a superior medicinal material because of its non-toxicity. In the Ming Dynasty’s Bencao Gangmu, Salvia Miltiorrhiza was described as having the properties of promoting blood circulation, Tongxin envelope and treating colic pain.

In traditional Chinese medicine, it was used to promote blood circulation and regulate menstruation, and was combined with various Chinese herbs such as Cyperus Rotundus, Angelica Sinensis, paeoniflorum and motherwort, can Help Women Menstrual Disorders or disorders; it also has a calming effect, with Semen Ziziphi SPINOSAE, semen platycladi and other can help patients with anxiety and insomnia; in addition, Salvia Miltiorrhiza can also remove blood stasis and relieve pain, mainly for the treatment of joint redness, swelling, heat and pain, and rheumatic pain and most of the blood stasis.

Pharmacopoeia Standards

Danshen SALVIAE MILTIORRHIZAE RADIX ET RHIZOMA is Miltiorrhiza bge.dried roots and rhizomes. Digging in Spring and autumn to remove silt and dry.

The rhizome of this product is short and thick, the apical part sometimes remains the stem base. The number of roots, long cylindrical, slightly curved, some branches with tendrils of fine roots, length 10～20 cm, diameter 0.3～1cm.

Surface Brownish red or dark brownish red, rough, longitudinally rugose. Old Root, loose skin, more show purple-brown, often show scale-like exfoliation. Hard and brittle, loose cross-section, there are cracks or slightly flat and dense, skin reddish brown, wood yellow or purple-brown, yellow-white vascular bundle, radial arrangement.

Slight Qi, slightly bitter taste. The cultivated product is more robust, the diameter 0. 5 ° 1.5 cm. Surface Reddish Brown, with longitudinal wrinkles, skin close not easy to peel off. Solid Texture, cross-section more flat, slightly cuticle-like.

The Effects of Salvia Miltiorrhiza

Salvia Miltiorrhiza Root Extract

The growing popularity of Danshen research may be intended to treat civilised diseases in modern humans, such as cardiovascular disease and cancer. Originally only in traditional Chinese medicine has a “dan-shen powder, Tongsiwu Soup” , promoting blood circulation and regulating menstruation, cooling blood and eliminating carbuncle and calming the mind effect, Now dan-shen is also used in clinical pharmacology.

In addition to treating cardiovascular diseases such as angina, myocardial infarction and ischemic stroke, it can also enhance myocardial contractility and expand coronary artery, increase its blood flow, and inhibit platelet aggregation and thrombosis. Some studies have shown that Salvia Miltiorrhiza can reduce blood lipid and inhibit the formation of coronary atherosclerotic plaque in rabbits.

At present, Chinese manufacturers of Salvia Miltiorrhiza into a pharmaceutical or capsule for the treatment and prevention of cardiovascular diseases. Moreover, Salvia Miltiorrhiza also has the function of protecting the liver, mainly because the cryptotanshinone in Salvia Miltiorrhiza can prevent the liver cell death caused by alcohol, and also can prevent the fat accumulation and the fatty acid production caused by alcohol.

Cancer, as well as cardiovascular disease, is one of the modern diseases and one of the important diseases that many doctors and physicians are trying to solve. The extract of Salvia Miltiorrhiza can effectively inhibit the metabolic mechanism of breast cancer, prostate cancer, colorectal cancer, lung cancer, liver cancer, blood cancer and gastric cancer cells, changes in the energy production of cancer cells and the required balance of nutrients, or inhibit the growth and proliferation of cancer cells, cancer cells to reduce the ability to metastasize and invasion.

Study on the extraction of Salvia Miltiorrhiza bunge and its mechanism

Ingredients of Salvia Miltiorrhiza extract

The most common technique for purifying herbal ingredients is high performance liquid chromatography (HPLC) , which separates the components of Salvia Miltiorrhiza individually. High performance liquid chromatography makes use of the fact that each component has a different distribution coefficient between the static and the dynamic phases, in short, a different affinity, resulting in a different length of time for each substance to remain in the column, the different substances in the sample can be separated out.

More than 70 components of Salvia Miltiorrhiza have been separated and purified, which can be divided into fat-soluble and water-soluble compounds. There are about 27 water-soluble phenolic acid derivatives, and the main active component is salvianolic acid, salvianolic acid A-K (Salvianolic acids A-K) , rosmarinic acid, etc. . The liposoluble components of Salvia Miltiorrhiza have been identified more than 50 diterpenoids, most of which are tanshinones, Tanshinone I, Tanshinone ⅡA, Tanshinone ⅡB, etc. . Tanshinone ⅡA(0.1 ~ 0.9%) is the main active component in lipophilicity.

Main effective components and efficacy of Salvia Miltiorrhiza extract

SALVIANOLIC ACID A

1. Treatment of Angina Pectoris, mainly acute myocardial infarction, and Central retinal artery

2. Inhibit lung cancer cells

SALVIANOLIC ACID B

1. It has anti-oxidation effect

2. Protect the brain from ischemia-reperfusion injury.

3. To reduce the damage of myocardial main heart Microvessel ischemia-reperfusion.

4. Prevent arteriosclerosis plaque formation

CRYPTOTANSHINONE

1. It has the function of anti-oxidation and anti-aging. To Angina Pectoris Main Myocardial Damage has the curative effect 3. It has bacteriostatic effect

TANSHINONE I

1. Treatment of Acne Principal Angina pectoris

2. It has a mild estrogenic activity

TANSHINONE IIA

1. Improve coronary artery circulation, inhibit thrombosis and improve Arrhythmi

2. Improve Myocardial contractility and promote myocardial regeneration.

3. Inhibit the proliferation and ability of a variety of cancer cells

TANSHINONE IIB

(1) reduce the volume of cerebral infarction and restore the nerve function

Danshensu

1. It can improve the microcirculation disturbance and the metabolic disturbance caused by cell ischemia and Hypoxia.                                                                     

2. Can dilate coronary arteries;                                                                                 

3. Has the inhibition platelet release vasoconstrictor material function;                 

4. It can inhibit the formation of Malondialdehyde and can be used to prevent and cure arteriosclerosis;                                                                                               

5. It’s an anticoagulant

Danshensu sodium

1. It has protective effect on myocardium                                                             

2. Inhibition of platelet aggregation and anticoagulation                                         

3. Anti-bacterial and anti-inflammatory and enhance the body’s immune function

4. Anti-arteriosclerosis and hypolipidemic effect                                                   

5. Anti-thrombosis, promoting blood circulation and removing stasis                  

6. Scar therapy prevents excessive wound healing                                              

7. Coronary artery dilatation                                                                                 

8. Treatment of liver injury                                                                                      

9. ANTI-CEREBRAL ISCHEMIA injury effect

The results of compound utility study on Salvia Miltiorrhiza bunge. Water-soluble salvianolic acids, mainly salvianolic acid B, are one of the most studied salvianolic acids.

SALVIANOLIC ACID B has antioxidant properties, scavenging free radicals in the body and inhibiting Lipid peroxidation reactions. Its antioxidant capacity is higher than that of vitamins C, E and Mannitol, which are currently common antioxidants, is now known as one of the high-quality antioxidant natural compounds.

SALVIANOLIC ACID B also protects against cerebral ischemia, reduces myocardial and cardiac microvascular ischemia-reperfusion injury, and prevents the formation of arteriosclerosis plaques SALVIANOLIC ACID A is used for Angina Pectoris, acute myocardial infarction and Central retinal artery embolism.

Another group of fat-soluble compounds contains cryptotanshinone, which has anti-oxidation, anti-aging, anti-angina and myocardial damage have a certain effect, it also has bacteriostasis. The efficacy of Tanshinone II a has been studied many times. Therefore it can improve coronary circulation, inhibit thrombosis and improve cardiac arrhythmia, some studies have also shown that Tanshinone II a has a partial protective effect on anoxic anemia induced by brain injury in mice, and can prolong the time of tolerance to anoxic injury in mice, and reduce the myocardial damage induced by anoxic injury, it can also improve myocardial contractility, promote myocardial regeneration and inhibit the inflammatory reaction of myocardial infarction.

Further, Tanshinone IIA is also related to the clearance of free radicals in Myocardial Mitochondria, which can inhibit the oxidation of density Lipoprotein in Vivo, that is, the effect of anti-oxidation. However, because Tanshinone II a is not soluble in water, Sodium tanshinone II a sulfonate (Sodium Tanshinon II a Silatea) , a water-soluble substance obtained by sulfonation, can overcome this shortcoming and enable Tanshinone II A to dissolve in water without losing its function, many studies have also modified tanshinone to change its biological activity.

SALVIA MILTIORRHIZA Extract

Conventional Specification

In short, we know that Salvia Miltiorrhiza has many benefits, including the treatment of cardiovascular diseases and cancer. Most importantly.using high-throughput techniques, we can quickly understand the molecular mechanism of the action of Danshen compounds, and the information obtained will be more abundant and provide more research results than before, as a reference for therapeutic strategy and direction.